ncRNA name | Slug siRNA |
ncRNA Category | siRNA |
Disease name | cataract |
Species | Homo sapiens |
Tissues/Cell_line | human lens epithelial cell lines HLE-B3 |
Methods | luciferase reporter assay, siRNA transfection, qPCR, RT-PCR, immunostaining, immunoblot, chromatin immunoprecipitation |
Expression pattern | associated |
Functional description | TGFβ1 induces Slug expression and that the repression of E-cadherin production by TGFβ1 is mediated by the induction of Slug in lens epithelial cells. The TGFβ1-mediated repression of E-cadherin was significantly inhibited by Slug siRNA. |
PubMed ID | 17525203 |
Year | 2007 |
Title | Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells. |
Drug-related ncRNA | NO |
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